Ehlers Danlos Syndrome Types

They also have thin translucent skin that bruises very easily. Vascular EDS formerly categorized as type 4 is identified by skin that is thin translucent extremely fragile and bruises easily.

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The Ehlers-Danlos syndromes comprise a clinically and genetically heterogeneous group of heritable connective tissue disorders which are characterized by joint hypermobility skin hyperextensibility and tissue friability.

Ehlers danlos syndrome types. It is also characterized by fragile blood vessels and organs that can easily rupture. Ehlers-Danlos syndrome type VIIA and VIIB result from splice-junction mutations or genomic deletions that involve exon 6 in the COL1A1 and COL1A2 genes of type I collagen. The EDS Support UK website.

Arthrochalasis multiplex congenita The History of EDS Arthrochalasia Type Hass and Hass 1958 proposed presence of a distinct entity of congenital flaccidity of the joints which they called arthrochalasis multiplex congenita and which may or may not involve skin changes. Ehlers-Danlos syndromes are a group of disorders which share common features including easy bruising joint hypermobility loose joints skin that stretches easily skin hyperelasticity or laxity and weakness of tissues. Vascular variant of EhlersDanlos syndrome.

Despite this grouping and their common name each type is a distinct condition caused by a different gene mutation. This syndrome is clinically heterogeneous and has been classically divided. Type VI is recessively inherited.

Types I II and III are autosomal dominant with an unknown biochemical origin. The Ehlers-Danlos syndromes are currently classified into thirteen subtypes. Byers PH et al.

In all but the hypermobile subtype hEDS genetics variants have been identified as the cause for the disorder and are part of the diagnostic criteria. Am J Med Genet. Ehlers-Danlos syndrome EDS is the name given to a group of disorders that affect connective tissue and cartilage which provide structure to joints tissues organs and skin.

Hypermobile EDS - characterized primarily by joint hypermobility affecting both large and small joints which may lead to recurrent joint dislocations and subluxations partial dislocation. Richards AJ et al. These clinical features suggest consideration of the diagnosis which then needs to be confirme.

Ehlers-Danlos syndrome can affect the skin joints and blood vessels. People who have vascular Ehlers-Danlos syndrome often share distinctive facial features of a thin nose thin upper lip small earlobes and prominent eyes. Ehlers-Danlos syndrome classical type Classical EDS is a heritable disorder of connective tissue.

There are 13 types of Ehlers-Danlos syndromes EDS with a significant overlap in features. The skin is often soft and may be mildly hyperextensible. Under the current 2017 classification system 13 types of EDS are identified many of which are linked to mutations in at least 20 different genes.

EhlersDanlos syndrome type VII VIIA VIIB. A single base mutation in COL5A2 causes Ehlers-Danlos syndrome type II. The most common type is called hypermobile Ehlers-Danlos syndrome.

It results from a mutation in the gene that. Hypermobile Ehlers-Danlos syndrome hEDS is generally considered the least severe type of EDS although significant complications primarily musculoskeletal can and do occur. Patients are affected with joint hypermobility skin hyperextensibilty and skin fragility leading to atrophic scarring and significant bruising.

COL3A1 mutation result in type III collagen production. Ehlers-Danlos syndromes are inherited in the genes that are passed from parents to offspring. Other types of EDS include classical EDS vascular EDS and kyphoscoliotic EDS.

Main types of Ehlers-Danlos syndromes EDS There are 13 types of EDS most of which are very rare. Type IV also called vascular Ehlers-Danlos syndrome 4 is autosomal dominant and involves the arteries GI tract uterus and skin. This means that a child cannot inherit a different type of EDS to the one their parent has.

Hypermobile EDS hEDS is the most common type. In the Villefranche Nosology six subtypes were recognized. The Ehlers-Danlos syndromes are a group of genetic connective tissue disorders which are currently classified in a system of thirteen types.

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